Babu L Tekwani Selected Research

Malaria

12/2022	Quantitative analysis of primaquine and its metabolites in human urine using liquid chromatography coupled with tandem mass spectrometry.
8/2022	Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers.
9/2021	Primaquine Loaded Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), and Nanoemulsion (NE): Effect of Lipid Matrix and Surfactant on Drug Entrapment, in vitro Release, and ex vivo Hemolysis.
1/2017	Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.
10/2016	Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.
1/2016	Methemoglobinemia Hemotoxicity of Some Antimalarial 8-Aminoquinoline Analogues and Their Hydroxylated Derivatives: Density Functional Theory Computation of Ionization Potentials.
6/2015	Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery.
10/2014	In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.
12/2013	Methemoglobin generation by 8-aminoquinolines: effect of substitution at 5-position of primaquine.
6/2013	CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.

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Babu L Tekwani Research Topics

Disease

25	Malaria 12/2022 - 01/2002
8	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2020 - 02/2010
7	Infections 08/2018 - 12/2006
6	Nervous System Diseases (Neurological Disorders) 07/2022 - 02/2010
6	Glucosephosphate Dehydrogenase Deficiency 02/2022 - 11/2009
6	Vivax Malaria 02/2022 - 02/2013
6	Neoplasms (Cancer) 01/2018 - 05/2004
5	Visceral Leishmaniasis (Kala Azar) 01/2023 - 12/2006
5	Hemolysis 12/2021 - 04/2010
5	Parasitic Diseases (Parasitic Disease) 01/2018 - 06/2003
4	Parkinson Disease (Parkinson's Disease) 09/2021 - 02/2010
3	Methemoglobinemia 01/2021 - 04/2010
3	African Trypanosomiasis (Nagana) 04/2018 - 02/2005
3	Alzheimer Disease (Alzheimer's Disease) 02/2018 - 07/2006
3	Hemolytic Anemia 10/2016 - 10/2013
3	Body Weight (Weight, Body) 10/2016 - 12/2014
3	Leishmaniasis 11/2012 - 09/2003
2	Neglected Diseases 06/2023 - 12/2015
2	Wounds and Injuries (Trauma) 01/2017 - 12/2016
2	Chagas Disease (American Trypanosomiasis) 02/2012 - 02/2005
1	Neuroblastoma 07/2022
1	COVID-19 10/2020
1	Schizophrenia (Dementia Praecox) 01/2018
1	Snake Bites (Snake Bite) 01/2017
1	Fever (Fevers) 10/2016
1	Arthritis (Polyarthritis) 10/2016
1	Mental Disorders (Mental Disorder) 10/2016
1	Ataxia (Dyssynergia) 07/2015
1	Blackwater Fever 06/2013
1	Parkinsonian Disorders (Parkinsonism) 02/2010
1	Parasitemia 11/2009
1	Pneumonia (Pneumonitis) 06/2009
1	Hepatocellular Carcinoma (Hepatoma) 02/2009

Drug/Important Bio-Agent (IBA)

18	Primaquine FDA Link 12/2022 - 12/2006
14	Antimalarials (Antimalarial Agents)IBA 02/2022 - 12/2007
10	Monoamine Oxidase (MAO)IBA 07/2022 - 02/2010
6	8-aminoquinolineIBA 12/2022 - 12/2006
6	Oxidoreductases (Dehydrogenase)IBA 07/2022 - 02/2010
5	Chloroquine (Aralen)FDA LinkGeneric 01/2023 - 06/2009
4	LipidsIBA 12/2021 - 01/2002
4	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 09/2021 - 08/2014
4	AlkaloidsIBA 06/2013 - 06/2003
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 11/2009
3	EnzymesIBA 06/2015 - 07/2006
3	hemozoinIBA 02/2005 - 01/2002
2	Lipid NanoparticlesIBA 12/2021 - 09/2021
2	Surface-Active Agents (Surfactants)IBA 12/2021 - 09/2021
2	FlavonoidsIBA 09/2021 - 11/2020
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2020 - 08/2010
2	acacetinIBA 02/2019 - 10/2016
2	Eflornithine (Ornidyl)FDA Link 04/2018 - 02/2005
2	MethemoglobinIBA 01/2016 - 12/2006
2	tafenoquineIBA 07/2015 - 12/2006
2	artemisinin (artemisinine)IBA 12/2009 - 09/2003
2	NAD (NADH)IBA 05/2009 - 09/2004
1	SterolsIBA 06/2023
1	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 07/2022
1	quinone (benzoquinone)IBA 02/2022
1	SolutionsIBA 09/2021
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 10/2020
1	Histones (Histone)IBA 01/2020
1	Histone Deacetylase InhibitorsIBA 01/2020
1	AcridinesIBA 01/2018
1	Harmine (Telepathine)IBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	virodhamineIBA 01/2018
1	EndocannabinoidsIBA 01/2018
1	Analgesics (Analgesic Drugs)IBA 01/2017
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2017
1	AntiemeticsIBA 01/2017
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2017
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	UbiquitinIBA 01/2017
1	desmethoxyyangoninIBA 01/2017
1	Vorinostat FDA Link 12/2016
1	polyalthic acidIBA 12/2015
1	Antidepressive Agents (Antidepressants)IBA 07/2015
1	ThioredoxinsIBA 06/2015
1	Propolis (Bee Bread)IBA 11/2014
1	Tigecycline (Tygacil)FDA Link 10/2014
1	Carbolines (Beta-Carbolines)IBA 08/2014
1	Quinine (Quinson)FDA Link 06/2013
1	resazurinIBA 12/2012
1	CarbazolesIBA 11/2012
1	DiaminesIBA 02/2012
1	Antiparasitic Agents (Antiparasitics)IBA 02/2012
1	Dapsone FDA Link 04/2010
1	AntioxidantsIBA 02/2010
1	miltefosine (Impavido)IBA 01/2010
1	Amino Acids FDA Link 11/2009
1	Malate Dehydrogenase (Dehydrogenase, Malate)IBA 05/2009
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 05/2009
1	SaltsIBA 02/2009
1	manzamine AIBA 02/2009
1	Amphotericin B (Amphotericin)FDA LinkGeneric 01/2009
1	prosopilosidineIBA 01/2009

Therapy/Procedure

2	Therapeutics 01/2021 - 10/2013
2	Traditional Medicine (Folk Remedies) 10/2016 - 06/2009
1	Mass Drug Administration 10/2016
1	Oral Administration 11/2009